Nowadays, a cancer diagnosis notice is more like a “death notice” for many families. Did you know that there is a difference between men and women in the incidence and mortality of various cancers? In general, men have about 20% higher cancer incidence and 40% higher mortality than women. The study also found that women had more side effects from chemotherapy and were more likely to develop thyroid cancer. Tracing back to the source, genetic and molecular factors are thought to be responsible for these differences, but the specific mechanisms involved are poorly understood.

A study by the Institute for Biomedical Research (IRB Barcelona) in Barcelona, Spain, recently found that the “behind-the-scenes players” responsible for the tumor differences between the sexes. The results were published in the journal Science Advances.

“We have identified the likely manipulators responsible for the tumor differences between male and female flies,” said Cayetano González, head of the laboratory at the IRB Cell Division in Barcelona.

In this work, researchers analyzed brain tumor development in the vinegar fly Drosophila melanogaster. Drosophila melanogaster has been used in scientific research as a model organism for more than a hundred years, and through them, researchers have discovered many proteins that are closely related to human cancer. In recent decades, various experimental models of human cancer, such as leukemia, neuroblastoma, glioblastoma, and ovarian cancer, have been developed in this animal model.

Specifically, the researchers observed that male flies had more aggressive brain tumors and were more likely to develop malignant tumors than females. They also found that protein expression levels were significantly elevated in brain tumor cells of male flies compared to female flies. Notably, these proteins are also present in humans.

Among these discovered proteins, the researchers focused on Phf7, which is also present in humans. However, in Drosophila, PHF7 is only present in male Drosophila tumor cells and shows strong invasiveness. When the researchers removed this protein from male flies, the tumors were significantly less invasive and returned to levels similar to female flies.

“Our results suggest that proteins responsible for the differences between male and female tumors can be regulated to reduce the malignancy associated with the sex of the affected individuals,” explains Kerry Cristina Molnar, a post-doctoral researcher at the IRB in Barcelona, who led the study.

González added: “Understanding the molecular basis of sex-related differences in cancer incidence and development allows us to find specific treatments for men and women.”

The interpretation of enzymes in the modern industry certainly does not refer to yeast, but to proteins with catalytic functions. As a natural catalyst, enzymes promote various chemical reactions in cells and play a vital role in the existence of living organisms. From the concept of enzymes, to the mature industrial enzyme production, it has probably gone through 130-40 years. The Greek translation of the enzyme is “in yeast”, meaning from yeast. In 1897, after the methods of disruption for yeast, the extract obtained had the function of converting glucose into alcohol and carbon dioxide. Since then, people have begun to identify and explore “some biological macromolecules can catalyze chemical reactions.”

Compared with traditional chemical catalysis, the characteristics of protein catalysis/enzyme catalysis are high quality and less waste. This is one of the reasons why the enzyme industry has risen in the past 40 years. The development of modern biotechnology is also an important driving force for the enzyme industry to move forward. Contemporary biotechnology, such as sequencing technology, protein engineering (enzyme engineering), fermentation, and bioprocessing, are all contributing to development and production. More complex and efficient enzyme products. It is believed that in the near future, the enzyme industry will only continue to expand and penetrate into more areas where the traditional chemical industry is difficult to expand.

The practical application of enzymes has been very extensive, including technology industry, food manufacturing, animal feed, organic synthesis and other fields.

In the field of application of these enzymes, the most common one should be the detergent manufacturing industry. The application of detergent and enzymes can be traced back to the 1960s. It was found that enzymes can catalyze the degradation of stubborn stains at relatively mild temperatures. Enzymes can also be naturally degraded as proteins without any environmental stress. The enzymes added to the current washing powder mainly include: protease, lipase, amylase, cellulase. Protease accounts for a large proportion. It is worth mentioning that almost all proteases in the detergent industry today are found in Bacillus species.

In addition to washing powder, what is the application of enzymes in the textile industry? The most common should be the enzymatic treatment of wool fabrics. As early as the 1980s, people began to use protease to treat wool fabrics to prevent shrinkage. Traditional wool fabrics require a chlorine-hercosett process to prevent shrinkage, but this method is not environmentally friendly, and later enzyme treatment is much better. In addition to the production of enzymes, the food industry’s demand for enzymes is also quite large. For example, in the global enzyme industry sales in 2018, the food industrial enzyme sales reached 1.5 billion US dollars, and in terms of enzyme products, the demand grows fast.

In the food industry, the most common enzyme applications should be amylase and amyloglucosidase hydrolyzed starch. The hydrolyzed starch produces small molecular monosaccharides or polysaccharides that give the food a sweet taste. In addition to this, there is an example in which glucose isomerase is used to catalyze glucose to produce fructose syrup.

Enzymes, in other words, are just proteins. Since there are only a lot of enzymes for industrial use in the future, it is known that the future development and optimization of catalytic proteins are essential. So what is enzymes development and optimization?

If you are an enzyme company owner and want to produce enzymes, you definitely want your enzymes to have low production costs, high product stability, and high enzyme catalyzed efficiency. But most of the enzymes found in nature do not have these characteristics, then you either go to the natural world to find enzymes that are more in line with production requirements, or to modify existing enzymes to meet your expectations. This is called development and optimization.

So let us dive right into the question: Why Donna Bella Cosmetics? We at The Pop Shop did some deep research on this company and will share everything we discovered. A brief background of Donna Bella below will provide some insight into this company and explain why these cosmetics are one not to pass on.

Known also as Beauty Cosmetics USA, which was established in 2001, started manufacturing products for a small boutique in Beverly Hills, California. They are now located in Chatsworth, California and are an established cosmetics distributor. A private label skincare manufacturer serving professional salon markets and OTC pharmaceuticals around the world. Donna Bella uses scientists that are professionally trained to meet customer demands by producing the highest quality custom formulations.

Manufacturing
Abiding by all regulations of quality control, Donna Bella has an approved manufacturing facility, as outlined by the U.S. Food and Drug Administration (FDA) and Good Manufacturing Practice (GMP). Their staff produces and manufactures products of top-rated quality. With state of the art technology and machinery, they perform compounding, filling, and packaging of almost every type of cosmetic, fragrance and OTC product including creams, lotions, gels, and ointments. Using the finest in organic, raw materials and herbal extracts, Donna Bella keeps you looking young and beautiful all day long.

Quality Control
We thoroughly looked into their Quality Control Laboratory and found that it is equipped to perform all required testing protocols. Assuring adherence to Good Manufacturing Practices as outlined by government licensing agencies is a priority. This includes raw material analysis and evaluation. Laboratory analysis of products, long-term stability, process, microbiology, product/package compatibility, and methods validation testing is always done.

Donna Bella’s commitment to quality extends through every phase, from development to manufacturing to packaging. The Quality Control Department is closely involved with every aspect of daily production and provides ongoing training to their staff.

Made in the USA
Donna Bella Cosmetics are manufactured in the USA. The products continue to meet the cosmetic needs of men and women in over 115 countries worldwide. They are truly dedicated to the health and preservation of facial skin. The cosmetic products use the finest ingredients and latest advances in skincare technology. Founder, Danny Aslan created this company with a small kiosk and a grand vision. A few years later, Danny graduated to wholesale distribution and the company grew much larger from there.

In Conclusion
Today, decades of cosmetic research and a dedication to the quality of their products have created a reputation that speaks for itself. The Pop Shop 2003 is now a direct authorized distributor for Donna Bella. We have raised the question: Why Donna Bella Cosmetics? The answer is plain to see from the review above but we want to go further. We use the products ourselves every day and find them to be just as described, truly awesome!

Donna Bella focuses on manufacturing high-quality luxury products at competitive prices. While flashy packaging and clever advertising campaigns can create hype, they firmly believe that product quality is the key to maintaining loyalty and rapport with their customers. We have a review video for you to watch Here.

For them, putting your “best face forward” isn’t just an old adage, it’s a way of life.

Recommended Donna Bella Products

Signature Edition Bio Anti-Aging Thermal Mask: Eliminates the appearance of wrinkles, thermal (Heat) mechanism to open pores, anti-aging treatment, renews skin tone and texture.

24K DMAE Instant Lifting Serum: Lines and wrinkles disappear, hydrates and helps repair damaged skin, helps to firm and tone skin.

Signature Edition Caviar Deep Facial Peeling: Micro-extraction lifts surface debris, re-balances skin’s hydration, attacks only dead skin cells, unclogs and purifies the skin.

24K Deep Moisturizer all skin type: Minimizes fine lines, imperfections, and wrinkles, powerful anti-oxidant day cream, helps relieve dry and flaky skin.

Signature Edition Collagen Radiance Renewal Mask: Reduces the appearance of fine lines and wrinkles, brightens and renews skin tone and texture, diminishes hyper-pigmentation and minimizes pores.

Caviar 60 Second Face Lift: Removes wrinkles, eliminate hooded and puffy eyes, promotes instant brow lift, and offers an instant face-lift in about 60 seconds.