Proteins that Controls Sex-linked Disparities in Cancers Found

Nowadays, a cancer diagnosis notice is more like a “death notice” for many families. Did you know that there is a difference between men and women in the incidence and mortality of various cancers? In general, men have about 20% higher cancer incidence and 40% higher mortality than women. The study also found that women had more side effects from chemotherapy and were more likely to develop thyroid cancer. Tracing back to the source, genetic and molecular factors are thought to be responsible for these differences, but the specific mechanisms involved are poorly understood.

A study by the Institute for Biomedical Research (IRB Barcelona) in Barcelona, Spain, recently found that the “behind-the-scenes players” responsible for the tumor differences between the sexes. The results were published in the journal Science Advances.

“We have identified the likely manipulators responsible for the tumor differences between male and female flies,” said Cayetano González, head of the laboratory at the IRB Cell Division in Barcelona.

In this work, researchers analyzed brain tumor development in the vinegar fly Drosophila melanogaster. Drosophila melanogaster has been used in scientific research as a model organism for more than a hundred years, and through them, researchers have discovered many proteins that are closely related to human cancer. In recent decades, various experimental models of human cancer, such as leukemia, neuroblastoma, glioblastoma, and ovarian cancer, have been developed in this animal model.

Specifically, the researchers observed that male flies had more aggressive brain tumors and were more likely to develop malignant tumors than females. They also found that protein expression levels were significantly elevated in brain tumor cells of male flies compared to female flies. Notably, these proteins are also present in humans.

Among these discovered proteins, the researchers focused on Phf7, which is also present in humans. However, in Drosophila, PHF7 is only present in male Drosophila tumor cells and shows strong invasiveness. When the researchers removed this protein from male flies, the tumors were significantly less invasive and returned to levels similar to female flies.

“Our results suggest that proteins responsible for the differences between male and female tumors can be regulated to reduce the malignancy associated with the sex of the affected individuals,” explains Kerry Cristina Molnar, a post-doctoral researcher at the IRB in Barcelona, who led the study.

González added: “Understanding the molecular basis of sex-related differences in cancer incidence and development allows us to find specific treatments for men and women.”

Effective Ayurvedic Capsules To Improve Brain Sharpness And Concentration

Brain problems can happen to anyone in any age. Depression is a common brain problem now a days and can happen due to any reason. Work pressure, emotional disturbance and environment affects brain and decreases a person’s ability to work. There are electrochemicals in brain which are responsible for functioning of brain and lack of these can cause problems. Vital nutrients are needed to nourish these electrochemicals and therefore diet plays an important role in maintaining proper brain activities. A person suffering from brain problems is unable to concentrate on things and forgets frequently about them. Brain gives late response to the activities due to slow movement of the electrochemicals that carry signal from organs to brain. This sometimes can cause frustration and anger that in turn further slows down brain activities.

Those who do not eat properly are unable to overcome this problem and need supplements to enhance memory. In spite of eating good diet, brain does not function properly because of the toxins present in blood. Beverages and alcohol also increase amount of toxins in blood. When an organ fails to purify the excess quantity of toxins, this impure blood upon reaching brain causes damage to cells and obstructs from providing energy. Cells do not provide enough energy to perform task and cause sleepiness and fatigue. Stress and depression further increase consumption of these elctrochemicals more than their production. Brahmpushpi capsules provide vital nutrients, vitamins and proteins necessary for production of brain elctrochemicals. Serious illnesses like jaundice and diabetes highly affect functioning of brain. Heavy medication used to cure these diseases slows down growth of cells. But these ayurvedic capsules to improve concentration reduce the bad effects of medicines on cells and keep them active.

The herbs used in Brahmpushpi capsules are Jatamansi, Shankhpushpi, Shatavari, Gorakhmundi, Chandi Bhasma, Jyotishmati, Gold Bhasma, Buch, Salam Mishri, Brahmi, Unab,Kachnar, Gurhal, Asalo, Ustekhadus and Brahmadandi. These herbs stop release of stress related hormones and induce sleep that helps brain to relax. These ayurvedic capsules to improve brain sharpness act as memory boosters, mood stabilizers, mind relaxants, brain stimulants, anti-stress and anti-depressants. The potent herbs improve brain sharpness, mental attention, retention power and learning capabilities. Cooling properties of the herbs relax central nervous system, control unsteady emotions and treat memory problems. These capsules stimulate intelligence, enhance memory and are effective in the treatment of memory loss. Some herbs serve as cooling tonic for nerves and are beneficial in drowsiness. These ayurvedic capsules to improve brain sharpness help in building strong memory and providing natural relief from headache and migraine. These
herbs possess anti inflammatory properties that prevents inflammation during hyperactivity and helps to control anger. These effective herbs enhance generation of new cells and help in quick healing in case of head injury.

New technologies are used to manufacture these ayurvedic capsules to improve brain sharpness naturally. Use these capsules regularly to enhance sharpness and concentration. It is advised to consume these capsules for 4-6 months to see amazing changes. These ayurvedic capsules to improve concentration also reduce anxiety, depression and fatigue and increase memory power, response activity and analyze power making brain more alert.

Kashyap – Another Ace Shuttler in the Making

Parupalli Kashyap is not exactly what you call an ‘up and coming’ badminton player. Infact, he has been on the badminton circuit for quite a while now, slowly building upon his reputation and working on his repartee. He might be quite as well-known as his peers who are heavy weights such as Mahesh Bhupathi, Leander Paes, Sania Mirza, Saina Nehwal et al but this 26 year old is well on the road to cementing his place in the badminton field. The year 2012 has been particularly an important milestone in Parupalli Kashyap profile and career graph.

Kashyap enrolled into S.M. Arif’s training camp in Hyderbad, India, when he was just eleven years old. He briefly trained with the Padukone Academy in Bangalore before he moved on to Gopichand Academy, presided over by the former All England Open Badminton Champion- Pullela Gopichand. His professional career did not kick off until the year 2005 when he won the boys’ singles title at the National Junior Open Badminton Championships, while representing Andhra Pradesh. He started participating in International Tournaments the following year.

His first significant movement was when he defeated Przemysław Wacha, the then World No. 19, at the pre-quarter finals. The players had another show down few months down the lane, where again Kashyap emerged successful. This win gave him and his mentor the confidence boost they needed. The same year, he represented India at the 2006 Asian Games. He then proceeded to capture a gold medal for Andhra Pradesh at the 33rd National Games. Year 2007 was equally advantageous to the prolific player. He went on to win other International tournaments. In 2008, he was the runner up at the Thailand International, Spanish Open as well as the Toulouse Open. His only notable achievemnt in 2009 was coming in third at the Singapore Super Series. The following year he won a bronze medal at the 2010 Commonwealth Games. He also reached the semi final round of the Indian Open Grand Prix that year.

After a rather uneventful 2011, he managed to be a semi finalist at the 2012 Djaram Indonesia Open. He created Indian Badminton history when he reached the quarterfinals of the 2012 London Olympics, becoming the first Indian male to do so. This elevated his worldwide ranking to a 19th position. His latest triumph at the Syed Modi International India Grand Prix coupled with Parupalli Kashyap statistics promoted him to a sixteenth rank.